Mechanism of Action

Anastrozole is a potent and highly selective non-steroidal aromatase inhibitor.

In postmenopausal women, estradiol is produced mainly through the conversion of androstenedione to estrone by the aromatase enzyme complex in peripheral tissues. Estrone is subsequently converted to estradiol.

Reducing circulating estradiol levels has been shown to provide therapeutic benefits in women with breast cancer. Studies have demonstrated that a daily dose of 1 mg anastrozole reduces estradiol levels in postmenopausal women by more than 80%.

Anastrozole has no progestogenic, androgenic, or estrogenic activity.

Clinical studies have also shown that doses up to 10 mg daily do not affect cortisol or aldosterone secretion. Therefore, corticosteroid replacement therapy is not required.

Indications:

AREMED® 1 mg is indicated for:

• Treatment of hormone receptor-positive breast cancer in postmenopausal women.
• Treatment of advanced hormone receptor-positive breast cancer in postmenopausal women.
• Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women.
• Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women who have completed 2–3 years of adjuvant tamoxifen therapy.

Contraindications

AREMED® 1 mg should not be used in the following cases:

• Pregnancy or breastfeeding.
• Hypersensitivity to anastrozole or any of the product's ingredients.

Storage Conditions

Store at a temperature not exceeding 25°C.

Keep out of the reach and sight of children.

Shelf Life

5 years

Do not use after the expiry date stated on the package.

Prescription Status

Prescription Only Medicine (Rx)

Manufacturer / Marketing Authorization Holder : Remedica Ltd. Aharnon Street, Limassol Industrial Estate, 3056 Limassol, Cyprus